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2019-nCoV NSP7 Protein

Recombinant full-length viral NSP7 was expressed in E. coli using a C-terminal His tag.
Catalog No. C19N7-E541H

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Catalog No. Pack Size Price (USD)
C19N7-E541H-10 10 ug $160
C19N7-E541H-20 20 ug $226
C19N7-E541H-50 50 ug $360
C19N7-E541H-BULK BULK Contact Us  


Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). Coronavirus RNA genome encodes a complex replication machinery consisting of 16 viral non-structural proteins (NSPs). NSP7 and NSP8 stabilize regions of NSP12 (RNA-dependent RNA polymerase; RdRp) involved in RNA binding and are essential for a highly active NSP12 polymerase complex. NSP7 has been suggested to confer RNA-binding properties to the trimeric polymerase complex (2). NSP8 has been shown to act as an oligo(U)-templated polyadenylyltransferase and a robust (mono/oligo) adenylate transferase (3). The NSP7/NSP8/NSP12 polymerase complex associates with NSP14 which is required to safeguard coronavirus replication fidelity (2).

Gene Aliases:

NSP7: Non-structural protein 7

Genbank Number:


1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.

2. Subissi L, et al: One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. PNAS. U.S.A. 2014, 111: E3900–E3909.

3. Tvarogova J, et al: Identification and characterization of a human coronavirus 229E nonstructural protein 8-associated RNA 3'-terminal adenylyltransferase activity. Virol. 2019, 368: 779-782.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

Approx 9 kDa


Sample purity data. For lot specific data, please refer to the respective datasheet.

Product Datasheets

There are no related publications available for this product.


Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology


  2019-nCoV NSP8 Protein, C19N8-E541H

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   2019-nCoV Nucleocapsid (N) Protein, C19NP-G242H

  2019-nCoV Spike protein S1 (IHU), C19S1-G231RH



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