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2019-nCoV Nucleocapsid (N) Protein

Recombinant full-length 2019-nCoV Nucleocapsid (N) Protein was expressed in E. coli cells with a C-terminal His tag.
Catalog No. C19NP-G242H


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Catalog No. Pack Size Price (USD)
C19NP-G242H-10 10 ug $100
C19NP-G242H-20 20 ug $190
C19NP-G242H-50 50 ug $290
C19NP-G242H-100 100 ug $435
C19NP-G242H-BULK BULK Contact Us  


Overview:

CoV N-protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoproteins or nucelocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as such as actin reorganization, host cell cycle progression, and apoptosis (2). N-protein is abundantly expressed during infection and antibodies against N-protein have been detected in confirmed cases of Covid-19. Therefore, N-protein is a potent antigen that provides basis for future vaccine and diagnostic kit development (3).


Gene Aliases:

Nucleoprotein, Nucleocapsid protein, NC, Protein N.


Genbank Number:


References:


1. McBride R, et al: The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014, 6:2991-3018.

2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681

3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618‐623.


Specific Activity:

Binding of Anti-2019-nCoV N-Protein Antibody (C19NP-60H) to immobilized 2019-nCoV Nucleocapsid (N) Protein (C19NP-G242H) determined by ELISA using Goat anti-human Fc-HRP.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

52 kDa



Product Datasheets



There are no related publications available for this product.


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  Anti 2019-nCoV N-Protein hIgG Antibody, HRP conjugated, C19NP-60DH


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