Recombinant 2019-nCoV Spike protein S1 (A222V) (16-685) was expressed in CHO cells using a C-terminal His- tag.
Catalog No. C19S1-G233H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C19S1-G233H-10 | 10 ug | $100 | |
C19S1-G233H-20 | 20 ug | $190 | |
C19S1-G233H-50 | 50 ug | $290 | |
C19S1-G233H-100 | 100 ug | $435 | |
C19S1-G233H-BULK | BULK | Contact Us |
Overview:
Novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world since 2020 (1). The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits, S1 and S2 is known to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) and facilitate viral entry into the host cell (2). A variant of SARS-CoV-2 carrying A222V mutation in the spike protein, also designated as lineage B.1.177, originated in Spain and then spread rapidly across Europe. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization (3).
Gene Aliases:
2019-nCoV s1, SARS-CoV-2 spike S1, SARS-CoV-2 S1, novel coronavirus spike s1, nCov spike s1, coronavirus spike S1.
Genbank Number:
References:
1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89. 2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. Nature. 2020, 581:215-220. 3. Harvey WT, et al: SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev. Microbiol. 2021, 19:409–424.
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular weight:
Approx. MW 130 kDa (calculated MW~76 kDa).
Purity:
Activity:
There are no related publications available for this product.
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