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2019-nCoV 3CLpro, Active

Recombinant full-length 2019-nCoV 3CLpro, part of a large replicase polyprotein 1ab (S3264-Q3569), was expressed in E. coli cells with an N-terminal His tag.
Catalog No. C19CL-G241H

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Catalog No. Pack Size Price (USD)
C19CL-G241H-05 5 ug $160
C19CL-G241H-10 10 ug $226
C19CL-G241H-20 20 ug $320
C19CL-G241H-50 50 ug $450
C19CL-G241H-BULK BULK Contact Us  


SARS-CoV-2 3C-like proteinase (3CLpro) is the nonstructural protein number 5, also a cysteine protease, that is released from the virally encoded polyprotein by extensive proteolytic processing. The 3CLpro cleaves the C-terminus of the large replicase polyprotein 1ab (~790 kDa) at no fewer than 11 sites (1). Inhibiting the activity of this enzyme would block viral replication (2). The functional importance of 3CLpro in the viral life cycle makes this protease an attractive target for the development of drugs directed against SARS and other coronavirus infections (3).

Gene Aliases:

SARS-CoV-2 3CLpro; NSP5; Mpro

Genbank Number:


1. Hegyi, A. et al: Conservation of substrate specificities among coronavirus main proteases. J Gen Virol. 2002,83:595-599.

2. Zhang L. et al: Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 2020, 368:409-412.

3. Anand K. et al: Coronavirus main proteinase (3CLpro) structure: Basis for design of anti-SARS drugs. Science. 2003, 300:1763-1767.

Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

35 kDa

Product Datasheets

There are no related publications available for this product.


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