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Anti 2019-nCoV Spike Protein mIgG Antibody

Recombinant monoclonal antibody with human Fab and mouse Fc region that can be detected with conjugated anti-mouse antibody in immunoassays.
Catalog No. C19S1-61MH


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Catalog No. Pack Size Price (USD)
C19S1-61MH-20 20 ug $165
C19S1-61MH-100 100 ug $325
C19S1-61MH-BULK BULK Contact Us  


Overview:

The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2) (3). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).

References:


1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.

2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.

3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235


Specificity :

Recognizes the 2019-nCoV Spike protein


Cross Reactivity:

SARS-CoV spike protein


Host Isotype / Clone#:

Human Fab-mouse Fc


Aliases:

Anti-SARS-CoV 2 Spike Protein Antibody


Stability:

1yr at –20oC from date of shipment.
Store product at –20oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Product shipped on ice packs.


Assay Data:

Binding of Human anti-2019-nCoV spike (mFc) (C19S1-61MH) to immobilized 2019-nCoV Spike protein RBD (C19SD-G241H) determined by ELISA using Goat anti-human Fab and Goat anti-mouse IgG (G32-62G) secondary antibodies.



Product Datasheets



There are no related publications available for this product.


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