METTL16 (Methyltransferase-like protein 16) is an RNA N6-methyltransferase that methylates adenosine residues at the N6 position of a subset of RNAs. METTL16 methylates the 3’ UTR of the SAM synthetase (MAT2A) mRNA and U6 snRNA (1,2), thereby regulating S-adenosylmethionine homeostasis as well as pre-mRNA splicing. These modifications on viral RNAs are believed to influence the expression of viral genes, the replication of virus and the generation of progeny virions (3).
1. Shima, H. et al: S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 2017,21:3354–3363.
2. Warda, AS. et al: Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 2017,18:2004–2014.
3. Dang, W. et al: N6-methyladenosine and viral infection. Front. Microbiol. 2019,10:417.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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