Overview:

Methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) form a stable heterodimer core complex that catalyzes N6-methyladenosine (m6A) RNA methylation in mammalian cells. m6A is an abundant internal modification in messenger RNA and long non-coding RNA. It functions in multiple aspects of developmental regulation, cell cycle progression, cell fate, and the heat shock stress response by affecting aspects of RNA metabolism such as pre-mRNA processing, translation efficiency, transcript stability and miRNA biogenesis.

Gene Aliases:

METTL3: IME4; M6A; MT-A70; Spo8
METTL14: None

Genbank Number:

NM_019852
NM_020961

References:

1. Liu J. et al: A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 2014; 10: 93–95

2. Wang X. et al: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex. Nature 2016; 534:575-578

3. Wang P. et al: Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases. Mol. Cell 2016; 63(2):306-317