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LOXL3 siRNA Set I

LOXL3 is a pool of three individual synthetic siRNA duplexes designed to knock-down human LOXL3 mRNA expression. Each siRNA is 19-25 bases in length.
Catalog No. L263-911


For enquiry on all siRNA Sets email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
L263-911-05 5 nmol $655
L263-911-20 20 nmol $1205
L263-911-50 50 nmol $2085
L263-911-BULK BULK Contact Us  


Overview:

LOXL3 is a member of the lysyl oxidase gene family. This family is essential to the biogenesis of connective tissue. The lysyl oxidase gene family encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin (1). LOXL3 is highly expressed in central nervous system, uterus, heart, and leukocyte (1). LOXL3 plays an important role in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis.


Gene Aliases:

LOXL


Genbank Number:


References:


1. Zhong, Z. et al: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994 Apr 1;264(5155):95-8.

2. Tian, S. S. et al: Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood. 1994 Sep 15;84(6):1760- P53.


Specificity:

LOXL3 siRNAs are designed to specifically knock-down human LOXL3 expression.


Reconstitution Protocol:

Each siRNA duplex is supplied as 2.5nmol per tube (for example 6 x 2.5nmol = 3 x 5nmol per duplex). Briefly centrifuge one tube per duplex (maximum RCF 4,000g) to collect lyophilized siRNA at the bottom of the tube. Resuspend each 2.5nmol tube in 50 ul of DEPC-treated water (included in kit), which results in a 1x stock solution (50 uM). Gently pipet the solution 3-5 times to mix and avoid the introduction of bubbles. Optional: aliquot 1x stock solutions for storage.


Storage and Stability:

The lyophilized powder is stable for at least 4 weeks at room temperature. It is recommended that the lyophilized and resuspended siRNAs are stored at or below -20oC. After resuspension, siRNA stock solutions ≥2 uM can undergo up to 50 freeze-thaw cycles without significant degradation. For long-term storage, it is recommended that the siRNA is stored at -70oC. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Format:

Lyophilized powder



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Metabolic Disorder


RELATED PRODUCTS


  LOX Protein, L260-31G


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