Recombinant human KDM4A (1-886) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K424-31G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K424-31G-20 | 20 ug | $215 | |
| K424-31G-50 | 50 ug | $435 | |
| K424-31G-BULK | BULK | Contact Us |
Overview:
KDM4A or lysine (K)-specific demethylase 4A is a member of the Jumonji domain 2 (JMJD2) family that encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. KDM4A functions in euchromatin to remove histone methylation marks that are associated with active transcription (1). KDM4A also act as a trimethylation-specific demethylase those converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor (2).
Gene Aliases:
JMJD2A; JHDM3A; KIAA0677
Genbank Number:
References:
1. Klose, R. J. et.al: The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature 442: 312-316, 2006.
2. Whetstine, J. R. et.al: Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125: 467-481, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~150 kDa
There are no related publications available for this product.
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