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ATP-dependent DNA helicase RecQ, Active

Recombinant full-length E. coli ATP-dependent DNA helicase RecQ was expressed in E. coli using C-terminal His-tag.
Catalog No. AH01-E311H


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Catalog No. Pack Size Price (USD)
AH01-E311H-50 50 ug $180
AH01-E311H-100 100 ug $270
AH01-E311H-200 200 ug $405
AH01-E311H-500 500 ug $708
AH01-E311H-BULK BULK Contact Us  


Overview:

RecQ helicases catalyze double-stranded DNA unwinding in the 3’ to 5’ direction, which is driven by ATPase activity that is dependent on a bivalent cation (1). RecQ helicases are important in coordinating genome maintenance and preserving genomic integrity in prokaryotes and eukaryotes (2). E. coli RecQ plays an important role in resuming DNA replication at stalled replication forks after repairing UV-induced DNA damage (3). They are also important in preventing future chromosomal abnormalities that result from DNA damage (3).


Gene Aliases:

RecQ


Genbank Number:


References:

1. Sharma, S. et al: Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J, 2006; 398(3): 319-337. 2. Bennet, R. J., Keck, J. L.: Structure and function of RecQ DNA helicases. Crit Rev Biochem Mol Biol., 2004; 39(2): 79-97. 3. Hishida, T. et al: Role of the Escherichia coli RecQ DNA helicase in SOS signaling and genome stabilization at stalled replication forks. Genes Dev., 2004; 18(15): 1886-1897.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage and Stability:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

Approx. 70kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cell Cycle


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