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Single-stranded DNA binding protein

Recombinant full-length E. coli Single-stranded DNA binding protein was expressed in E. coli with an N-terminal His tag.
Catalog No. SS01-C501H


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Catalog No. Pack Size Price (USD)
SS01-C501H-50 50 ug $45
SS01-C501H-200 200 ug $110
SS01-C501H-500 500 ug $195
SS01-C501H-1000 1000 ug $298
SS01-C501H-BULK BULK Contact Us  


Overview:

Single-stranded DNA binding protein (SSB) in E. coli is involved in DNA replication, repair, and recombination (1). SSB enhances helix destabilization by DNA helicases thus preventing reannealing of single-stranded DNA and nuclease digestion during DNA replication (1). E. coli SSB is required for methyl-directed mismatch repair, induction of the SOS response, and recombinational repair (1). SSB interacts with DNA helicase RecQ of the RecF-recombination pathway and stimulates helicase activity (2). SSB also stabilizes replication origins, primosome assembly, plays a role in primosome assembly, enhances replication fidelity and polymerase processivity, and promotes polymerase binding to template DNA (1,2).


Gene Aliases:

ssb, exrB, lexC,


Genbank Number:


References:

1. Meyer, R. R., Laine, P. S. The single-stranded DNA-binding protein of Escherichia coli. Microbiol Rev. 1990, 54(4): 342-380. 2. Shereda, R. D. et al. SSB as an organizer/mobilizer of genome maintenance complexes. Crit Rev Biochem Mol Biol. 2008, 43(5): 289-318.


Purity:

Sample Purity graph. For specific information on a given lot, see related technical data sheet


Storage and Stability:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle


RELATED PRODUCTS


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  DUB Substrate III, N263-57


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