Overview:

Human methyltransferase like proteins (METTL) are part of a large protein family characterized by the presence of binding domains for S-adenosyl methionine, a co-substrate for methylation reactions (1). The methyltransferase-like protein 12 (METTL12) is localized in the mitochondrial matrix and methylates the lysine-368 that is localized near the active sites of citrate synthase (CS) (2). In response to alterations in metabolite levels, the METTL12-mediated methylation regulates the CS activity (3). Possible functions for the methylation of Lys-368 are in controlling substrate channeling itself, or in influencing protein–protein interactions in the metabolon (2).

Gene Aliases:

CS-KMT; METTL12; U99HG

Genbank Number:

NM_001043229

References:

1. Ignatova, V.V. et al: The interactome of a family of potential methyltransferases in HeLa cells. Scientific reports. 2019; 9.1: 1-9. 2. Rhein, V.F. et al: Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase. FEBS letters. 2017; 591.12: 1641-1652. 3. Malecki, J. et al: Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation. Journal of Biological Chemistry. 2017; 292.43: 17950-17962.