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KT-5823

PKG inhibitor
Catalog No. P78-900


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Catalog No. Pack Size Price (USD)
P78-900-100 100 ug $138
P78-900-500 500 ug $644
P78-900-BULK BULK Contact Us  


Overview:

Selective protein kinase G inhibitor (Ki = 0.23, 4 and > 10 uM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity (IC50 of 60 nM) in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 uM. Cell permeable.

References:


1. H Kase et al. Biochem. Biophys. Res. Commun. 1987 142:436

2. Gadbois et al . Proc.Natl.Acad.Sci.1996 89:8626.

3. Murthy and Makhlouf. Am.J.Physiol. 1995 268:C171.

4. Smolenski et al. Naunyn Schmiedebergs Arch.Pharmacol. 1998 358:134


CAS Registry Number:

126643-37-6


Molecular Formula:

C29H25N3O5


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

495.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml); or DMF (20 mg/ml)


Aliases:

None


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



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