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Nilotinib

BCR-ABL inhibitor
Catalog No. A03-901


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Catalog No. Pack Size Price (USD)
A03-901-05 5 mg $61
A03-901-25 25 mg $204
A03-901-BULK BULK Contact Us  


Overview:

A novel, selective BCR-ABL inhibitor. More potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM) (1). Induces apoptosis (2).

References:


1. E Weisberg et al. Br. J. Cancer 2006 94:1765

2. S Verstovsek et al. Leuk. Res. 2006 30:1499


CAS Registry Number:

641571-10-0


Molecular Formula:

C28H22F3N7O


Appearance:

Off-white powder


Melting Point:

N/A


Molecular Weight:

529.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:


1. 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)- 5-(trifluoromethyl) phenyl]-3- [(4-pyridin-3-ylpyrimidin-2-yl) amino] benzamide

2. AMN-107


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer



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