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PP2

SRC family kinase inhibitor
Catalog No. S19-900B


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Catalog No. Pack Size Price (USD)
S19-900B-05 5 mg $165
S19-900B-25 25 mg $660
S19-900B-BULK BULK Contact Us  


Overview:

Potent and selective Src family kinase inhibitor. Inhibits Lck (IC50=4 nM), Fyn (IC50=5 nM), and Hck (IC50=5 nM).Shows weaker inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50=100 uM) and JAK2 (IC50=50 uM). Useful for probing the involvement of Src family tyrosine kinases in cellular signaling.

References:


1. F. Carlomagno et al.; J. Clin. Endocrinol. Metab. 2003 8:1897

2. J.K. Chen et al.; J Biol Chem. 2000 275:13789

3. M. Yoshizumi et al.; J. Biol. Chem. 2000 275:11706

4. J.H. Hanke et al.; J. Biol. Chem. 1996 271:695


CAS Registry Number:

172889-27-9


Molecular Formula:

C15H16ClN5


Appearance:

Off-white solid


Melting Point:

N/A


Molecular Weight:

301.8


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml); or ethanol (3 mg/ml, warm)


Aliases:

3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo [3,4-d] pyrimidin-4-amine


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store stock solutions at -20oC for one month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway


RELATED PRODUCTS


  PP1/PP2A Substrate, P50-58

  PP2B Substrate, P51-58


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