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Vandetanib

VEGFRK inhibitor
Catalog No. F11-900


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Catalog No. Pack Size Price (USD)
F11-900-10 10 mg $72
F11-900-50 50 mg $248
F11-900-BULK BULK Contact Us  


Overview:

A potent and selective inhibitor of VEGFR2, ( KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases (1). Inhibits colony formation in seven cancer cell lines (2). Displays anti-angiogenesis activity (3).

References:


1. SR Wedge et al. Cancer Res. 2002 62:4645

2. F Ciardiello et al. Clin. Cancer Res. 2003 9:1546

3. RS Herbst et al. Expert Opin. Investig. Drugs 2007 16:239


CAS Registry Number:

443913-73-3


Molecular Formula:

C22H24BrFN4O2


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

475.4


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (30 mg/ml); or ethanol (10 mg/ml, warm)


Aliases:


1. 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl) methoxy] quinazoline

2. ZD6474


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



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