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Vatalanib 2HCl

VEGFRK inhibitor
Catalog No. F11-900D


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Catalog No. Pack Size Price (USD)
F11-900D-10 10 mg $72
F11-900D-50 50 mg $226
F11-900D-BULK BULK Contact Us  


Overview:

Potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM) (1). Weaker inhibitor of other tyrosine kinases including PDGFR-beta (IC50 = 580 nM), c-KIT (IC50 = 730 nM), FLT-4 (IC50 = 660 nM) and c-FMS (IC50 = 1.4 uM). Inactive against the EGFR, c-SRC, v-ABL, and protein kinase Calpha (IC50 > 10 uM). Inhibits the growth of multiple myeloma cells in the bone marrow microenvironment2.

References:


1. J.M. Wood et al. Cancer Res. 2000 60:2178

2. B. Lin et al. Cancer Res. 2002 62:5019


CAS Registry Number:

212141-51-0


Molecular Formula:

C20H15CIN4•2HCl


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

419.7


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml, warm); or water (100 mg/ml)


Aliases:


1. N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride

2. CGP-79787

3. PTK-787

4. ZK222584


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



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