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Wortmannin

PI3K inhibitor
Catalog No. P27-900B


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Catalog No. Pack Size Price (USD)
P27-900B-01 1 mg $83
P27-900B-05 5 mg $303
P27-900B-BULK BULK Contact Us  


Overview:

Potent, selective, and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM). Cell-permeable.

References:


1. Arcaro and Wymann Biochem J. 1993 296:297

2. Powis et al Cancer Res. 1994 54:2419

3. Liu et al Chem .Biol. 2005 12:99


CAS Registry Number:

19545-26-7


Molecular Formula:

C23H24O8


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

428.4


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (20 mg/ml)


Aliases:

None


Storage and Stability:

Store desiccated as supplied at -20C for up to 1 year. Make and use fresh solutions. Do not store stock solutions.



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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