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CID-2011756

PKD1 inhibitor
Catalog No. P72-901


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Catalog No. Pack Size Price (USD)
P72-901-05 5 mg $94
P72-901-25 25 mg $380
P72-901-BULK BULK Contact Us  


Overview:

Potent and selective ATP-competitive inhibitor of protein kinase D (PKD). IC50=3.2, 0.6 and 0.7 uM for PKD1, 2 and 3 respectively. Inhibits phorbol ester-induced PKD activation in LNCaP prostate cancer cells. Cell permeable.

References:


1. ER Sharlow et al. PLoS One 2011 6:e25134


CAS Registry Number:

638156-11-3


Molecular Formula:

C22H21ClN2O3


Appearance:

Tan powder


Melting Point:

189-192oC


Molecular Weight:

396.9


Purity:

≥98% (TLC); NMR (Conforms)


Solubilization:

Soluble in DMSO (>50mg/ml); or ethanol (8mg/ml, warm).


Aliases:

5-(3-Chlorophenyl)-N-[4-(4-morpholinylmethyl) phenyl]-2-furancarboxamide


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



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