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CZC-54252 HCl

LRRK2 inhibitor
Catalog No. L10-901


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Catalog No. Pack Size Price (USD)
L10-901-05 5 mg $105
L10-901-25 25 mg $435
L10-901-BULK BULK Contact Us  


Overview:

Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM (1). Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM) (1). The G2019S mutant is a common mutation found in familial Parkinson’s disease patients (2). Cell permeable.

References:


1. LH Wang et al. J. Immunol. 1999 162:3897

2. N Meydan et al. Nature 1996 379:645


CAS Registry Number:

1199911-27-9


Molecular Formula:

C22H25ClN6O4S ∙ HCl


Appearance:

Off-white solid


Melting Point:

N/A


Molecular Weight:

541.5


Purity:

≥98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:

N-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl) phenyl] amino]-4-pyrimidinyl] amino] phenyl] methanesulfonamide hydrochloride


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Neurobiology



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