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Erlotinib HCl

EGFR kinase inhibitor
Catalog No. E10-900C


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Catalog No. Pack Size Price (USD)
E10-900C-10 10 mg $50
E10-900C-100 100 mg $160
E10-900C-BULK BULK Contact Us  


Overview:

Potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM) (1). Potent inhibitor of mutant JAK2-V617F (2). Weaker inhibitor of ErbB-2 kinase (Ki = 1 uM) ErbB-4 kinase (Ki = 1.5 uM) (3).

References:


1. JD Moyer et al. Cancer Res. 1997 57:4838

2. Z Li et al. J. Biol. Chem. 2007 282:3428

3. ER Wood et al. Cancer Res. 2004 64:6652


CAS Registry Number:

183319-69-9


Molecular Formula:

C22H23N3O4 ∙ HCl


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

429.9


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (18 mg/ml, warm)


Aliases:

N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, hydrochloride


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases



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