cFMS kinase inhibitor
Catalog No. C74-901
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Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases (1). Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 uM) (1). Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone (1). Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice (2). Active in vivo.
1. JG Conway et al Proc. Natl. Acad. Sci. USA 2005 102:16078
2. RT Paniagua et al. Arthritis Res. Ther. 2010 12:R32
CAS Registry Number:
≥98% (TLC); NMR (Conforms)
May be dissolved in DMSO (40 mg/ml)
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Metabolic Disorder