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GW2580

cFMS kinase inhibitor
Catalog No. C74-901


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Catalog No. Pack Size Price (USD)
C74-901-05 5 mg $94
C74-901-25 25 mg $369
C74-901-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases (1). Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 uM) (1). Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone (1). Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice (2). Active in vivo.

References:


1. JG Conway et al Proc. Natl. Acad. Sci. USA 2005 102:16078

2. RT Paniagua et al. Arthritis Res. Ther. 2010 12:R32


CAS Registry Number:

870483-87-7


Molecular Formula:

C20H22N4O3


Appearance:

Off-white solid


Melting Point:

209-210oC


Molecular Weight:

366.4


Purity:

≥98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (40 mg/ml)


Aliases:

5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Metabolic Disorder



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