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H-89 2HCl

PKA inhibitor
Catalog No. P51-900B


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Catalog No. Pack Size Price (USD)
P51-900B-05 5 mg $83
P51-900B-25 25 mg $391
P51-900B-BULK BULK Contact Us  


Overview:

Protein kinase A inhibitor (IC50= 135 nM). Also inhibits S6K1, MSK1,ROCKII, PKBalpha and MAPKAP-K1b (IC50= 80, 120, 270, 2600 and 2800 nM respectively). Induces apoptosis. Cell permeable.

References:


1. Vitolo et al Proct.Natl.Acad.Sci. 2002 99:13217.

2. Lochner and Moolman. Cardiovasc.Drug Rev. 2006 24:261.

3. Yamada et al. Pathobiology 2006 73:1.

4. D. Findik et al. J. Cell Biochem. 1995 57:12


CAS Registry Number:

127243-85-0


Molecular Formula:

C20H20BrN3O2S ∙ 2HCl


Appearance:

White to off-white powder


Melting Point:

N/A


Molecular Weight:

519.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml); or water (10 mg/ml)


Aliases:

N-[2-[[3-(4-Bromophenyl)-2-propenyl] amino] ethyl]-5-isoquinolinesulfonamide dihydrochloride


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



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