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ZM-306416

VEGFR inhibitor
Catalog No. F11-900B


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Catalog No. Pack Size Price (USD)
F11-900B-05 5 mg $83
F11-900B-25 25 mg $380
F11-900B-BULK BULK Contact Us  


Overview:

Potent inhibitor of VEGF receptor tyrosine kinase, inhibiting KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM). Displays ca 4-fold selectivity over FGFR-1. Orally active (100 mg/kg, rat) (1).

References:


1. LF Hennequin et al J. Med. Chem. 1999 42:5369


CAS Registry Number:

690206-97-4


Molecular Formula:

C16H13ClFN3O2


Appearance:

Off-white solid


Melting Point:

N/A


Molecular Weight:

333.7


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (3 mg/ml); or ethanol (1 mg/ml)


Aliases:

4-[(4'-Chloro-2'-fluoro) phenylamino]-6,7-dimethoxyquinazoline


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



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