Catalog No. F11-900B
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Potent inhibitor of VEGF receptor tyrosine kinase, inhibiting KDR (IC50 = 100 nM) and Flt (IC50 = 2 uM). Displays ca 4-fold selectivity over FGFR-1. Orally active (100 mg/kg, rat) (1).
1. LF Hennequin et al J. Med. Chem. 1999 42:5369
CAS Registry Number:
>98% (TLC); NMR (Conforms)
May be dissolved in DMSO (3 mg/ml); or ethanol (1 mg/ml)
Storage and Stability:
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.
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Angiogenesis, Cancer, Cell Cycle, Neurobiology