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LY-294002

PI3K inhibitor
Catalog No. P27-900C


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Catalog No. Pack Size Price (USD)
P27-900C-05 5 mg $105
P27-900C-25 25 mg $413
P27-900C-BULK BULK Contact Us  


Overview:

Highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 = 0.31, 0.73, 1.06 and 6.60 uM for PI 3-Kbeta, PI 3-Kalpha, PI 3-Kdelta and PI 3-Kgamma respectively) (1). Inhibits autophagy in rat hepatocytes (IC50 = 10 uM) (2). An extremely useful tool for determining the role of PI 3-K in cellular signaling (3).

References:


1. CJ Vlahos et al. J. Biol. Chem. 1994 269:5241

2. EF Blomaart et al. Eur. J. Biochem. 1997 243:240

3. S Chasserot-Golaz et al. J. Neurochem. 1998 70:2347


CAS Registry Number:

154447-36-6


Molecular Formula:

C19H17NO3


Appearance:

White to pale-yellow powder


Melting Point:

182-183oC


Molecular Weight:

307.2


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (100 mg/ml)


Aliases:

2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling



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