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ZM-447439

Aurora B kinase inhibitor
Catalog No. A31-901


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Catalog No. Pack Size Price (USD)
A31-901-01 1 mg $72
A31-901-10 10 mg $237
A31-901-BULK BULK Contact Us  


Overview:

Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 uM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells.

References:


1. C Ditchfield et al J. Cell Biol. 2003 161:267

2. F Girdler et al J. Cell Sci. 2006 119:3664

3. F H Jung et al J. Med. Chem. 2006 49:955


CAS Registry Number:

331771-20-1


Molecular Formula:

C29H31N5O4


Appearance:

White solid


Melting Point:

N/A


Molecular Weight:

513.6


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:

(N-[4-[[6-Methoxy-7-[3-(4-morpholinyl) propoxy]-4-quinazolinyl] amino] phenyl] benzamide


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Ser/Thr Kinases



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