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U-0126

MEK1/2 inhibitor
Catalog No. M02-901


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Catalog No. Pack Size Price (USD)
M02-901-05 5 mg $204
M02-901-25 25 mg $666
M02-901-BULK BULK Contact Us  


Overview:

U-0126 is a novel, potent and selective MEK inhibitor (MEK1; IC50=72 nM, MEK2; IC50=58 nM) (1,2). Blocks the production of inflammatory cytokines and prostaglandin E2 in LPS-stimulated monocytes (3) and displays anti-inflammatory activity (4). An extremely useful tool for exploring pathways dependent on MEK activity.

References:


1. JV Duncia et al. Bioorg. Med. Chem. Lett. 1998 8:2839

2. MF Favata et al. J. Biol. Chem. 1998 273:18623

3. PA Scherle et al. J. Immunol. 1998 161:5681

4. BD Jaffee et al. Biochem. Biophys. Res. Commun. 2000 268:647


CAS Registry Number:

109511-58-2


Molecular Formula:

C18H16N6S2


Appearance:

White solid


Melting Point:

N/A


Molecular Weight:

380.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (35 mg/ml) or ethanol (2 mg/ml)


Aliases:

1,4-Diamino-2,3-dicyano-1,4-bis [2-aminophenylthio] butadiene


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



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