Home    >   Kinase Inhibitors

Fasudil HCl

ROCK inhibitor
Catalog No. R10-900


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
R10-900-10 10 mg $94
R10-900-50 50 mg $391
R10-900-BULK BULK Contact Us  


Overview:

Rho-associated kinase inhibitor (IC50 = 1.9 uM and 10.7 uM for Rho-associated kinase II and Rho-associated kinase respectively)(1). Inhibits other kinases including cyclic nucleotide-dependent protein kinases (1). Reduces tryptamine-evoked vasopressor responses (2). Attenuates bleomycin-induced pulmonary fibrosis in a mouse model (3). Clinically useful vasodilator.

References:


1. SP Davies et al. Biochem. J. 2000 351:95

2. MA Anwar et al. Vascul. Pharmacol. 2013 58:140

3. C Jiang et al. Int. J. Mol. Sci. 2012 13:8293


CAS Registry Number:

105628-07-7


Molecular Formula:

C14H17N3O2S ∙ HCl


Appearance:

White powder


Melting Point:

208-212oC


Molecular Weight:

327.8


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (75 mg/ml); or Water (100 mg/ml)


Aliases:


1. 1-(5-Isoquinolinesulfonyl) homopiperazine HCl

2. HA-1077


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox