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AG-1517

Tyrosine kinase inhibitor
Catalog No. K11-900B


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Catalog No. Pack Size Price (USD)
K11-900B-05 5 mg $83
K11-900B-25 25 mg $325
K11-900B-BULK BULK Contact Us  


Overview:

An ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFRK), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation (1). Inhibits the growth of a number of cancer cell lines (2). An extremely useful tool for exploring EGF-mediated cellular signaling (3).

References:


1. DW Fry et al. Science 1994 265:1093

2. M Bos et al. Clin. Cancer Res. 1997 3:2099

3. MP Tetreault et al. J. Cell. Biochem. 2008 105:1240


CAS Registry Number:

153436-54-5


Molecular Formula:

C16H14BrN3O2 ∙ HCl


Appearance:

White to off-white solid


Melting Point:

N/A


Molecular Weight:

396.7


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (5 mg/ml, warm)


Aliases:


1. 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride

2. PD-153,035

3. SU-5271

4. ZM-252868


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Metabolic Disorder, Ser/Thr Kinases



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