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Sunitinib malate

VEGFR, PDGFR inhibitor
Catalog No. F11-900G


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Catalog No. Pack Size Price (USD)
F11-900G-05 5 mg $94
F11-900G-25 25 mg $413
F11-900G-BULK BULK Contact Us  


Overview:

A potent inhibitor of multiple receptor tyrosine kinases including VEGFR, PDGFRbeta and Kit (Ki = 2-17 nM) (1). Also inhibits cFMS (IC50=7 nM) (2) and FLT3 (3). Potent inhibitor of angiogenesis (4). Clinically useful anticancer agent. Cell permeable.

References:


1. ED Deeks et al. Drugs 2006 66:2255

2. J Guo et al. Mol. Cancer. Ther. 2006 5:1007

3. AM O’Farrell et al. Blood. 2003 101:3597

4. R Roskoski et al. Biochem. Biophys. Res. Commun. 2007 356:323


CAS Registry Number:

341031-54-7


Molecular Formula:

C22H27FN4O2 ∙ C4H6O5


Appearance:

Orange solid


Melting Point:

N/A


Molecular Weight:

532.6


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (13 mg/ml, warm)


Aliases:


1. N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide malate

2. SU-11248


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



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