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Imatinib mesylate

BCR-ABL inhibitor
Catalog No. A03-901B


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Catalog No. Pack Size Price (USD)
A03-901B-20 20 mg $39
A03-901B-100 100 mg $105
A03-901B-BULK BULK Contact Us  


Overview:

Tyrosine kinase inhibitor specific for bcr-abl (IC50 = 38 nM) (1), PDGF-R (IC50 = 0.3 uM) (1) and c-kit (IC50 = 0.1 uM) (2). It is a clinically useful anti-cancer drug approved for the treatment of chronic myelogenous leukemia (3), gastrointestinal stromal tumors as well as several other cancers.

References:


1. E Buchdunger et al. Cancer Res. 1996 56:100

2. Heinrich et et al. Blood 2000 96:925

3. M Deininger et al. Pharmacol. Rev. 2003 55:401


CAS Registry Number:

220127-57-1


Molecular Formula:

C29H31N7O · CH3SO3H


Appearance:

White solid


Melting Point:

N/A


Molecular Weight:

589.7


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml); or water (50 mg/ml)


Aliases:


1. 4-[(4-Methyl-1-piperazinyl) methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl] amino]-phenyl] benzamide methanesulfonate

2. STI-571


Storage and Stability:

Store desiccated as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.


Molecular Structure:



Product Datasheets



RESEARCH AREAS

Cancer



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