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Sorafenib

RAF1 kinase inhibitor (and others)
Catalog No. R01-900


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Catalog No. Pack Size Price (USD)
R01-900-10 10 mg $50
R01-900-50 50 mg $182
R01-900-BULK BULK Contact Us  


Overview:

Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-beta (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM) (1). Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms (2). Inhibits activation of MAPK pathway and ERK phosphorylation (3). Induces caspase-independent apoptosis in melanoma cells (4). Clinically useful anticancer agent.

References:


1. SM Wilhelm et al. Cancer Res. 2004 64:7099

2. J Guo et al. Mol. Cancer Ther. 2006 5:1007

3. SM Wilhelm et al. Proc. Am. Assoc. Cancer Res. 2003 44:106609

4. DJ Panka et al. Cancer Res. 2006 66:1611


CAS Registry Number:

284461-73-0


Molecular Formula:

C21H16ClF3N4O3


Appearance:

Off-white powder


Melting Point:

204-206oC


Molecular Weight:

464.8


Purity:

>99% (TLC); NMR (Conforms)


Solubilization:

Soluble in DMSO (200 mg/ml); or Ethanol (3 mg/ml)


Aliases:


1. 4-(4-(3-(4-chloro-3 (trifluoromethyl) phenyl) ureido) phenoxy)-N-methylpicolinamide

2. BAY 43-9006


Storage and Stability:

Store desiccated as supplied at -20o for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



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