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Lestaurtinib

FLT3/TRKA inhibitor
Catalog No. F12-901


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Catalog No. Pack Size Price (USD)
F12-901-01 1 mg $160
F12-901-05 5 mg $622
F12-901-BULK BULK Contact Us  


Overview:

Potent and selective FLT3 inhibitor (IC50= 2.0 nM) (1,2). Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders (3).

References:


1. M Lewis et al. Expert Opin. Investig. Drugs 2003 12:1951

2. P Chen et al. J. Biol. Chem. 2005 280:5361

3. EO Hexner et al. Blood 2008 111:5663


CAS Registry Number:

111358-88-4


Molecular Formula:

C26H21N3O4


Appearance:

White to off-white solid


Melting Point:

N/A


Molecular Weight:

439.5


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (100 mg/ml); or ethanol (20 mg/ml)


Aliases:


1. CEP-701

2. KT-5555


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, ERK/MAPK Pathway, Receptor Tyrosine Kinases



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