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Dasatinib

SRC & BCR-ABL inhibitor
Catalog No. S19-901B


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Catalog No. Pack Size Price (USD)
S19-901B-05 5 mg $61
S19-901B-25 25 mg $127
S19-901B-BULK BULK Contact Us  


Overview:

Inhibits Src, Bcl/Abl and Lyn tyrosine kinases (IC50= 0.55, 3.0 and 8.5 nM respectively (1,2). Suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells (3).

References:


1. LJ Lombardo et al. J. Med. Chem. 2004 47:6658

2. S Nam et al. Cancer Res. 2005 65:9185

3. FM Johnson et al. Clin. Cancer Res. 2005 11:6924


CAS Registry Number:

302962-49-8


Molecular Formula:

C22H26ClN7O2S


Appearance:

White to off-white solid


Melting Point:

274-276oC


Molecular Weight:

488.0


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (200 mg/ml)


Aliases:


1. N-(2-chloro-6-methylphneyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide;

2. BMS-354825


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cytoplasmic Tyrosine Kinases, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, JAK/STAT Pathway



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