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Lapatinib

EGFR kinase inhibitor
Catalog No. E10-900D


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Catalog No. Pack Size Price (USD)
E10-900D-10 10 mg $61
E10-900D-50 50 mg $237
E10-900D-BULK BULK Contact Us  


Overview:

Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM) (1). Clinically useful agent for treatment of breast cancer (2-3). Cell permeable.

References:


1. ER Wood et al. Cancer Res. 2004 64:6652

2. HA Burris et al. Oncologist 2004 9:10

3. I Chu et al. Cancer Res. 2005 65:18


CAS Registry Number:

231277-92-2


Molecular Formula:

C29H26ClFN4O4S


Appearance:

Yellow powder


Melting Point:

136-140oC


Molecular Weight:

581.1


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

Soluble in DMSO (200 mg/ml)


Aliases:


1. N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]-2-furyl]quinazolin-4-amine

2. GW-572016


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases



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