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Genistein

Tyrosine kinase inhibitor (pan)
Catalog No. K11-900


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Catalog No. Pack Size Price (USD)
K11-900-10 10 mg $39
K11-900-50 50 mg $160
K11-900-BULK BULK Contact Us  


Overview:

A naturally occurring flavanoid with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase (1,2). Phytoestrogen (3) and agonist at GPR30 (4). Displays cancer chemopreventive activity (5).

References:


1. T Akiyama et al. J. Biol. Chem. 1987 262:5592

2. C Linassier et al. Biochem. Pharmacol. 1990 39:187

3. ZC Dang et al. J. Biol. Chem. 2003 278:962

4. A Vivacqua et al. Mol. Pharmacol. 2006 70:1414

5. FH Sarker et al. Cancer Metastasis. Rev. 2002 21:265


CAS Registry Number:

446-72-0


Molecular Formula:

C15H10O5


Appearance:

Yellow solid


Melting Point:

N/A


Molecular Weight:

270.2


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25 mg/ml) or ethanol (4 mg/ml)


Aliases:


1. 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

2. 4',5,7-Trihydroxyisoflavone


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 1 week.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Metabolic Disorder, Ser/Thr Kinases



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