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Gefitinib

EGFR inhibitor
Catalog No. E10-900


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Catalog No. Pack Size Price (USD)
E10-900-50 50 mg $72
E10-900-250 250 mg $281
E10-900-BULK BULK Contact Us  


Overview:

Potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM) (1). Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo (2). Enhances efficacy of cytotoxic agents (3). Inhibits growth factor production and angiogenesis (4). Clinically useful anticancer agent.

References:


1. J Baselga et al. Drugs 2000 60:33, Suppl. 1

2. D McKillop et al. Mol. Cancer Ther. 2005 4:641

3. FM Sirotnak et al. Clin. Cancer Res. 2000 6:4885

4. F Ciaradiello et al. Clin. Cancer Res. 2001 7:1459


CAS Registry Number:

184475-35-2


Molecular Formula:

C22H24ClFN4O3


Appearance:

Tan solid


Melting Point:

N/A


Molecular Weight:

446.9


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (40 mg/ml) or ethanol (4 mg/ml)


Aliases:


1. N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine;

2. ZD1839


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, PKA/PKC Pathway, Receptor Tyrosine Kinases



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