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AG-490

JAK2 inhibitor
Catalog No. J02-901


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Catalog No. Pack Size Price (USD)
J02-901-05 5 mg $55
J02-901-25 25 mg $182
J02-901-BULK BULK Contact Us  


Overview:

A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src.

References:


1. LH Wang et al. J. Immunol. 1999 162:3897

2. N Meydan et al. Nature 1996 379:645


CAS Registry Number:

133550-30-8


Molecular Formula:

C17H14N2O3


Appearance:

Tan powder


Melting Point:

N/A


Molecular Weight:

294.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (30 mg/ml) or ethanol (10 mg/ml)


Aliases:

(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cytoplasmic Tyrosine Kinases, Inflammation, JAK/STAT Pathway



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