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ZM-336372

c-Raf inhibitor
Catalog No. R01-901


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Catalog No. Pack Size Price (USD)
R01-901-05 5 mg $94
R01-901-25 25 mg $369
R01-901-BULK BULK Contact Us  


Overview:

Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50uM) with the exception of p38 (SAPK2a) (IC50=2uM) and SAPK2b (p38beta) (IC50=2uM). Induces a paradoxical >100-fold activation of c-Raf in whole cells. Induces apoptosis in a variety of cell lines. Cell permeable.

References:


1. CA Hall-Jackson et al. Chem. Biol. 1999 6:559

2. D Deming et al. J. Surg. Res. 2010 161:28


CAS Registry Number:

331771-20-1


Molecular Formula:

C23H23N3O3


Appearance:

Off white powder


Melting Point:

258-260oC


Molecular Weight:

513.6


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (25mg/ml)


Aliases:

3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)-amino]-4-methylphenyl]-benzamide


Storage and Stability:

Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20°C for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases



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