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PD-98059

MEK inhibitor
Catalog No. M02-900


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Catalog No. Pack Size Price (USD)
M02-900-05 5 mg $88
M02-900-25 25 mg $413
M02-900-BULK BULK Contact Us  


Overview:

Inhibitor of mitogen-activated protein kinase kinase (MKK/MEK). Acts via binding to the inactivated form of MEK, preventing its phosphorylation by cRAF or MEK kinase (IC50=2-7uM)

References:


1. DR Alessi et al. J. Biol. Chem. 1995 270:27489

2. DT Dudley et al. Proc. Natl. Acad. Sci. USA. 1995 92:7686


CAS Registry Number:

167869-21-8


Molecular Formula:

C16H13NO3


Appearance:

Yellow powder


Melting Point:

164-165oC


Molecular Weight:

267.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (6 mg/ml)


Aliases:

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 2'-Amino-3'-methoxyflavone


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases



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