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NPC-15437

PKC inhibitor
Catalog No. P61-900B


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Catalog No. Pack Size Price (USD)
P61-900B-01 1 mg $61
P61-900B-05 5 mg $303
P61-900B-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19uM) (1,2). It specifically interacts with the C1 domain of PKC (3). Important tool for assessing the role of PKC in various signaling pathways (4). Cell permeable. Active in vivo (4).

References:


1. JP Sullivan et al. Mol. Pharmacol. 1992 41:38

2. JP Sullivan et al. Agents Actions 1991 34:142

3. JP Sullivan et al. FEBS Lett. 1991 285:120

4. K Miyoshi et al. Eur. J. Pharmacol. 2007 562:208


CAS Registry Number:

141774-20-1


Molecular Formula:

C25H50N4O2 ∙ 2HCl


Appearance:

Light yellow to white powder


Melting Point:

N/A


Molecular Weight:

511.6


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in: water (10 mg/ml)


Aliases:

(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl) methyl] hexanamide dihydrochloride hydrate


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



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