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Necrostatin-1

RIP1 kinase inhibitor
Catalog No. R07-901


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Catalog No. Pack Size Price (USD)
R07-901-10 10 mg $116
R07-901-50 50 mg $358
R07-901-BULK BULK Contact Us  


Overview:

Inhibits cellular necroptosis a non-apoptotic cell death pathway which leads to necrosis (EC50 = 494 nM) (1). Inhibits receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM) the key upstream kinase in the necroptosis activation pathway (2,3). Reduces ischemic brain injury in a mouse model of stroke1 and inhibits myocardial death (4).

References:


1. A Degterev et al. Nat. Chem. Biol. 2005 1:112

2. A Degterev et al. Nat. Chem. Biol. 2008 4:313

3. A Linkermann et al. Kidney Int. 2012 81:751

4. CC Smith et al. Cardiovasc. Drugs Ther. 2007 21:227


CAS Registry Number:

4311-88-0


Molecular Formula:

C13H13N3OS


Appearance:

Yellow powder


Melting Point:

N/A


Molecular Weight:

259.3


Purity:

>98% (TLC: 1:9, CH3OH:CH2Cl2; Rf=0.6); NMR (Conforms)


Solubilization:

May be dissolved DMSO (25 mg/ml); or ethanol (6 mg/ml)


Aliases:


1. 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

2. Methylthiohydantoin-DL-tryptophan


Storage and Stability:

Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Ser/Thr Kinases



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