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LFM-A13

BTK inhibitor
Catalog No. B10-901


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Catalog No. Pack Size Price (USD)
B10-901-05 5 mg $83
B10-901-25 25 mg $325
B10-901-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits recombinant BTK with an IC50 = 2.5 uM (1) and has no activity at other protein kinases (including JAK1, JAK3, HCK, EGFR kinase and insulin receptor kinase) at concentrations up to 300 uM (2).

References:


1. S Mahajan et al. J. Biol. Chem. 1999 274:9587

2. A Vassilev et al. J. Biol. Chem. 1999 274:1646


CAS Registry Number:

62004-35-7


Molecular Formula:

C11H8Br2N2O2


Appearance:

Yellow powder


Melting Point:

145-146oC


Molecular Weight:

360.0


Purity:

98% (TLC: 2:8 CH3OH:CH2Cl2; Rf=0.53); NMR (Conforms)


Solubilization:

DMSO (10 mg/ml) and ethanol (15 mg/ml)


Aliases:

2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, NfkB Pathway



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