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GW-441756

NGFR inhibitor
Catalog No. N28-909


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Catalog No. Pack Size Price (USD)
N28-909-10 10 mg $160
N28-909-50 50 mg $611
N28-909-BULK BULK Contact Us  


Overview:

Potent, selective inhibitor of the NGF receptor tyrosine kinase A (TrkA) (IC50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Blocks TrkA-mediated gammaH2AX production (2) and apoptosis (3) in TrkA-overexpressing cells. Cell permeable.

References:


1. ER Wood et al. Bioorg. Med. Chem. Lett. 2004 14:953

2. EJ Jung et al. Exp. Mol. Med. 2008 40:276

3. EJ Wood et al. Mol. Cells Lett. 2008 26:12


CAS Registry Number:

504433-23-2


Molecular Formula:

C17H13N3O


Appearance:

Orange powder


Melting Point:

N/A


Molecular Weight:

275.1


Purity:

98% (TLC: 5% CH3OH: CH2Cl2; Rf=0.4) mixture of E and Z isomers


Solubilization:

: May be dissolved in DMSO (25 mg/ml); or Ethanol (100 mg/ml)


Aliases:

1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one


Storage and Stability:

Store desiccated as supplied at -20oC for up to 3 years. Store solutions at -20oC for up to 3 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, PKA/PKC Pathway, Receptor Tyrosine Kinases



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