Home    >   Kinase Inhibitors

GW-5074

c-Raf1 inhibitor
Catalog No. R01-901B


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
R01-901B-05 5 mg $105
R01-901B-25 25 mg $380
R01-901B-BULK BULK Contact Us  


Overview:

Specific inhibitor of cRaf-1 kinase (IC50=9 nM). Acts at ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective activity. Cell permeable.

References:


1. K Lackey et al. Bioorg. Med. Chem. Lett. 2000 10:223

2. PC Chen et al. J. Neurochem. 2004 90:595


CAS Registry Number:

220904-83-6


Molecular Formula:

C15H8Br2INO2


Appearance:

Off white powder


Melting Point:

267-268oC


Molecular Weight:

520.9


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (50 mg/ml)


Aliases:

3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JAK/STAT Pathway, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox