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GSK-690693 HCl

AKT inhibitor
Catalog No. A16-900


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Catalog No. Pack Size Price (USD)
A16-900-05 5 mg $127
A16-900-25 25 mg $512
A16-900-BULK BULK Contact Us  


Overview:

A novel ATP-competitive pan-specific Akt kinase inhibitor. (IC50s=2, 13, 9 nM for Akt1, 2 and 3 respectively)(1). Antitumor activity. Active in vivo. Induces hyperglycemia (2). Cell permeable.

References:


1. N Rhodes et al. Cancer Res. 2008 68:2366

2. MC Crouthamel et al. Clin. Cancer Res. 2009 15:217


CAS Registry Number:

937174-76-0


Molecular Formula:

C21H27N7O3 .HCl


Appearance:

Off white powder


Melting Point:

N/A


Molecular Weight:

426.0


Purity:

99% (HPLC); NMR (Conforms)


Solubilization:

May be dissolved in DMSO (10mg/ml); Water (30 mg/ml)


Aliases:

(S)-4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol. HCl


Storage and Stability:

Store desiccated as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


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