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GF-109203X

PKC inhibitor
Catalog No. P61-900


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Catalog No. Pack Size Price (USD)
P61-900-01 1 mg $105
P61-900-10 10 mg $171
P61-900-BULK BULK Contact Us  


Overview:

Potent and selective protein kinase C inhibitor with specificity for the alpha and beta1 isotypes. IC50=0.0084, 0.018, 0.210, 0.132 and 0.58 uM for alpha, beta1, delta, epsilon, and zeta respectively (1). An extremely useful tool for assessing the involvement of PKC in various signaling pathways (2,3).

References:


1. D Toullec et al. J. Biol. Chem. 1991 266:15771

2. T Bouschet et al. J. Biol. Chem. 2003 278:4778

3. G Robert et al. PLoS One 2009 4:e7889


CAS Registry Number:

133052-90-1


Molecular Formula:

C25H24N4O2


Appearance:

Red/orange powder


Melting Point:

N/A


Molecular Weight:

412.5


Purity:

98% (TLC); NMR (Conforms)


Solubilization:

Soluble in dimethyl formamide or DMSO (10mg/ml, warm to 40oC)


Aliases:


1. 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl) maleimide

2. Bisindolylmaleimide I


Storage and Stability:

Store desiccated as supplied at -20oC for up to 1 year. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases



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