Home    >   Kinase Inhibitors

Doramapimod

p38 MAP kinase inhibitor
Catalog No. M39-900


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
M39-900-05 5 mg $83
M39-900-25 25 mg $292
M39-900-BULK BULK Contact Us  


Overview:

Potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site (1). (IC50=18 nM). Displays anti-inflammatory activity (2) but differential effects on inflammatory genes (3). Cell permeable.

References:


1. C Pargellis et al. Nat. Struct. Biol. 2002 9:268

2. J Branger et al. J. Immunol. 2002 168:4070

3. H Joos et al. Br. J. Pharmacol. 2010 160:1252


CAS Registry Number:

285983-48-4


Molecular Formula:

C31H37N5O3


Appearance:

White to off-white crystalline solid


Melting Point:

136-140oC


Molecular Weight:

527.7


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved DMSO (50 mg/ml); or ethanol (30 mg/ml)


Aliases:


1. 1-[5-tert-butyl-2-(4-methylphenyl) pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy) naphthalen-1-yl] urea

2. BIRB-796


Storage and Stability:

Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 months.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway, Ser/Thr Kinases



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox