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Picropodophyllotoxin

IGF1R inhibitor
Catalog No. I02-901


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Catalog No. Pack Size Price (USD)
I02-901-05 5 mg $105
I02-901-25 25 mg $484
I02-901-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF1R) which is non-competitive with ATP (1). Displays no activity at IR, EGFR, FGFR or PDGFR. Inhibits IGF1R autophosphorylation IC50 ~ 1 nM (1). Displays antiproliferative activity in numerous tumor cell lines, IC50 = 0.05 - 15 uM (2). Exhibits antiangiogenic activitiy (3). Attenuates intimal hyperplasia after vascular injury (4). Active in vivo.

References:


1. A Girnita et al. Cancer Res. 2004 64:236

2. A Girnita et al. Clin. Cancer Res. 2006 12:1383

3. E Menu et al. Int. J. Cancer 2007 121:1857

4. A Razuvaev et al. J. Vasc. Surg. 2007 46:108


CAS Registry Number:

477-47-4


Molecular Formula:

C22H22O8


Appearance:

White powder


Melting Point:

222-224oC


Molecular Weight:

414.4


Purity:

>97% (TLC); NMR (Conforms)


Solubilization:

Soluble in DMSO (40 mg/ml)


Aliases:

(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one


Storage and Stability:

Store desiccated as supplied at ambient temperature for up to 1 year. Store solutions at -20oC for up to 1 month.


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cellular Stress, ERK/MAPK Pathway, Metabolic Disorder, Receptor Tyrosine Kinases



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