Home    >   Kinase Inhibitors

SU-4312

VEGFR, PDGFR inhibitor
Catalog No. F11-900F


For enquiry on all Kinase Inhibitors email us at orders@signalchem.com


Catalog No. Pack Size Price (USD)
F11-900F-05 5 mg $83
F11-900F-25 25 mg $325
F11-900F-BULK BULK Contact Us  


Overview:

Potent and selective inhibitor of VEGF receptor tyrosine kinase (Flk-1, KDR). Inhibits unactivated kinase 100-fold greater (IC50=0.04 uM) than activated kinase (IC50=4.0 uM ) (1). Weak inhibitor of PDGF receptor tyrosine kinase (IC50=19.4 uM) (2). Inhibits endothelial cell activation and angiogenesis in a mouse model of Alzheimers disease (3).

References:


1. RL Kendall et al. J. Biol. Chem. 1999 274:6453

2. L Sun et al. J. Med. Chem. 1998 41:2588

3. Schultheiss et al. Angiogenesis 2006 9:59


CAS Registry Number:

5812-07-7


Molecular Formula:

C17H16N2O


Appearance:

Orange powder


Melting Point:

N/A


Molecular Weight:

264.3


Purity:

>98% (TLC); NMR (Conforms)


Solubilization:

May be dissolved DMSO (25 mg/ml)


Aliases:


1. 3-(4-Dimethylaminobenzylidene)-1,3-dihydroindol-2-one

2. DMBI


Storage and Stability:

Storage, Stability and Shipping


Molecular Structure:



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Cancer, Cell Cycle, Neurobiology



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox